A team led by Prof. Gu Xiaofeng at the Biotechnology Research Institute of CAAS published an article titled "N6-methyladenine DNA modification in the human genome" in Molecular Cell. The study confirmed that 6mA is extensively present in the human genome, and the decrease of 6mA level of genomic DNA is closely related to the malignant phenotype of tumor and the poor prognosis of tumor patients. It revealed that the decrease of 6mA level of human genomic DNA may promote development, invasion and metastasis of tumor, while the increase of 6mA level inhibits development, invasion and metastasis of tumor.
Increase of genomic 6mA modification level represses tumorigenesis