The study on the structure of African swine fever virus found a variety of potential key epitopes of ASF virus, which provides important clues for revealing the mechanisms of ASF virus invading host cells and host antiviral immunity, and opens up new avenues for African swine fever vaccine development. The study of recombinant Eimeria as a vaccine vector showed that the co-immunization of multiple strains of recombinant Eimeria expressing different protective antigens of pathogens can enhance the protective immunity of the host. The result is of great significance for the development of new safe and efficient coccidiosis vaccines.

The results demonstrated firstly that mink enteritis virus (MEV) induces apoptosis through activation of p38 mitogen-activated protein kinase (MAPK) and the p53-mediated mitochondrial apoptotic pathway induced by NS1 protein, which sheds light on the molecular pathogenesis of MEV infection. The study revealed the molecular mechanism by which the H7N9 avian influenza virus rapidly acquires a PB2/E627K mutation that enhances the virus pathogenicity to humans, thus contributing to an in-depth understanding of the important scientific issue of how avian influenza viruses infect, adapt to, and transmit among mammalian hosts.

A proposed model for MEV NS1-induced mitochondrion-mediated apoptosis