188bet平台app官方哈尔滨兽医研究所

1、个人简历

张万江，男，博士，研究员，硕士生导师，188bet平台app官方哈尔滨兽医研究所动物细菌病创新团队首席科学家，哈尔滨兽医研究所所级“青年英才”入选者，黑龙江省高层次E类人才。主持国家自然基金、十三五国家重点研发计划子课题、黑龙江省自然科学基金、中国博士后基金等10余项课题。

研究方向为重要动物病原菌耐药性的产生、耐药菌/耐药基因的传播机制和治疗性药物的研发；重要细菌病多联多价疫苗创制和快速诊断技术和产品的研发。发表SCI论文40余篇，其中以第一或通讯作者在J Antimicrob Chemother、Antimicrob Agents Chemother、Int J Antimicrob Agents等本领域权威SCI期刊发表论文20余篇，累计影响因子超过100。获得国家发明专利4项，省部级领导批示1件，参编学术著作2部。目前担任Front Cell Infect Mi和Animals客座主编、Front Microbiol和J Integr Agr编委，现担任新疆农业大学和东北林业大学兼职硕士生导师。

2、联系方式

（1）研究方向：兽医药理与毒理学

（2）电话：0451-50151734

（3）邮箱：zhangwanjiang@www.comparadata.com

（4）通讯地址：哈尔滨市香坊区哈平路678号

3、教育经历

2001.09-2005.06 河南农业大学药物制剂学士

2005.09-2008.06 华南农业大学兽医药理与毒理学硕士

2008.09-2011.06 中国农业大学兽医药理与毒理学博士

4、工作经历

2012.02-2014.01 188bet平台app官方哈尔滨兽医研究所博士后

2014.02-2014.12 188bet平台app官方哈尔滨兽医研究所助理研究员

2015.01-2020.12 188bet平台app官方哈尔滨兽医研究所副研究员

2021.01至今 188bet平台app官方哈尔滨兽医研究所研究员

5、承担项目

1) “十三五” 国家重点研发计划项目：畜禽重要病原耐药性检测与控制技术研究（2016YFD0501304，2016.06-2021.06）， 65万元，主持子课题；

2) “十三五” 国家重点研发计划项目：畜禽重要细菌病病原学与流行病学研究（2017YFD0500102，2017.7-2021.06），74万元，主持子课题；

3) 黑龙江省自然科学基金优秀青年项目：动物源大肠杆菌多粘菌素耐药基因 mcr-1 的流行病学与传播机制研究（YQ2019C031，2019.7-2022.7），10万元，主持；

4) 国家自然科学基金青年基金项目：奶牛源耐甲氧西林金黄色葡萄球菌流行特点及甲氧西林耐药新机制研究（31201862，2013.1-2015.12），23万元，主持；

5) 公益性行业（农业）专项：动物源性沙门菌病防控技术研究与示范（201403054，2014.1-2018.12），105万，主要参与；

6) 中国博士后基金面上项目： bla _NDM-1基因引起鲍曼不动杆菌耐药与适应性代价研究（2012M520482，2012.1-2014.2），5万元，主持；

7) 中国博士后科学基金特别资助：鲍曼不动杆菌IV型分泌系统在耐药及致病中的作用研究（2013T60204，2013.8-2014.2），15万元，主持；

8) 兽医生物技术国家重点实验室课题：奶牛源葡萄球菌中 cfr 基因流行特点及传播机制研究（SKLVBP201317-3，2013.1-2013.12），10万元，主持；

9) 188bet平台app官方基本科研业务费专项：动物源细菌对磷霉素耐药及快速传播机制研究（Y2016JC27，2016.1-2017.12），20万元，主持。

6、代表论文与著作

1) Qin Yang, Yao Zhu, Stefan Schwarz, Lingli Wang, Wenyu Liu, Wenlin Yang, Siguo Liu, Wanjiang Zhang*. Integrative and conjugative elements in streptococci can act as vectors for plasmids and translocatable units integrated via IS 1216E . Int J Antimicrob Agents, 2023, 61(5):106793.

2) Yao Zhu, Qiu Xu, Stefan Schwarz, Shenye Yu, Lining Xia, Fang Xie, Wenlin Yang, Longyu Zhou, Longhua Lin, Wanjiang Zhang*. Identification of a novel MDR plasmid co-harbouring the carbapenem resistance gene bla _VIM-2 and tigecycline resistance gene cluster tmexCD1-toprJ1 in a Pseudomonas stutzeri isolate. J Antimicrob Chemother, 2023, 78(5):1309-1311.

3) Yao Zhu, Wenlin Yang, Stefan Schwarz, Qiu Xu, Qin Yang, Lingli Wang, Siguo Liu and Wanjiang Zhang*. Characterization of an MDR Lactobacillus salivarius isolate harbouring the phenicol-oxazolidinone-tetracycline resistance gene poxtA . J Antimicrob Chemother, 2022, 77(8):2125-2129.

4) Yao Zhu^#, Wenlin Yang^#, Stefan Schwarz, Qiu Xu, Qin Yang, Lingli Wang, Siguo Liu and Wanjiang Zhang*. Characterization of the novel optrA -carrying pseudo-compound transposon Tn 7363 and an Inc18 plasmid carrying cfr (D) in Vagococcus lutrae . J Antimicrob Chemother, 2022, 77(4):921-925.

5) Wenlin Yang^#, Qiu Xu^#, Qin Yang, Lingli Wang, Siguo Liu, Yao Zhu, Wanjiang Zhang*. Characterization of a novel RepA_N-family plasmid harbouring the phenicol-oxazolidinone resistance gene optrA in Enterococcus faecalis ST16 high-risk clone of goat origin. Vet Microbiol, 2022, 266:109340.

6) Yao Zhu, Changzhen Wang, Stefan Schwarz, Wenyu Liu, Qin Yang, Tian Luan, Lingli Wang, Siguo Liu and Wanjiang Zhang*. Identification of a novel tetracycline resistance gene, tet (63), located on a multiresistance plasmid from Staphylococcus aureus . J Antimicrob Chemother, 2021, 76(3):576-581.

7) Yao Zhu^#, Qin Yang^#, Stefan Schwarz, Wenlin Yang, Qiu Xu, Lingli Wang, Siguo Liu and Wanjiang Zhang*. Identification of a Streptococcus parasuis isolate co-harbouring the oxazolidinone resistance genes cfr (D) and optrA . J Antimicrob Chemother, 2021, 76(11):3059-3061.

8) Qin Yang, Yao Zhu, Stefan Schwarz, Lingli Wang, Wenyu Liu, Wenlin Yang, Tian Luan, Siguo Liu and Wanjiang Zhang*. A novel plasmid from Aerococcus urinaeequi of porcine origin co-harboring the tetracycline resistance genes tet (58) and tet (61). Vet Microbiol, 2021, 257:109065.

9) Yao Zhu, Wenyu Liu, Stefan Schwarz, Lei Liu, Wenlin Yang, Qin Yang, Lingli Wang, Tian Luan, Siguo Liu and Wanjiang Zhang*. Emergence of bla _NDM-11 carried by an IncX3 plasmid in Citrobacter freundii ST266 in China. J Glob Antimicrob Resist, 2021, 27:250-252.

10) Yao Zhu^#, Wenyu Liu^#, Stefan Schwarz, Changzhen Wang, Qin Yang, Tian Luan, Lingli Wang, Siguo Liu and Wanjiang Zhang* Characterization of a bla _NDM-1-carrying IncHI5 plasmid from Enterobacter cloacae complex of food-producing animal origin, J Antimicrob Chemother, 2020, 75(5):1140-1145.

11) Yao Zhu^#, Wanjiang Zhang^#, Stefan, Schwarz, Changzhen Wang, Wenyu Liu, Fuguang Chen, Tian Luan and Siguo Liu*. Characterization of a bla _IMP-4-carrying plasmid from Enterobacter cloacae of swine origin, J Antimicrob Chemother, 2019, 74:(7)1799-1806.

12) Fuguang Chen^#, Wanjiang Zhang^#, Stefan, Schwarz, Yao Zhu, Ruichao Li, Xin Hua and Siguo Liu*. Genetic characterization of an MDR/virulence genomic element carrying two T6SS gene clusters in a clinical Klebsiella pneumoniae isolate of swine origin, J Antimicrob Chemother, 2019, 74(6):1539-1544.

13) Wanjiang Zhang^#, Yao Zhu^#, Changzhen Wang, Wenyu Liu, Ruichao Li, Fuguang Chen, Tian Luan, Yanhe Zhang, Stefan Schwarz* and Siguo Liu*. Characterization of a multidrug-resistant porcine Klebsiella pneumoniae sequence type 11 strain coharboring bla _KPC-2and fosA3 on two novel hybrid plasmids, mSphere, 2019, 4:e00590-19.

14) Xiumei Wang^#, Yao Zhu^#, Xin Hua, Fuguang Chen, Changzhen Wang, Yanhe Zhang, Siguo Liu* and Wanjiang Zhang*. F14:A-:B- and IncX4 Inc group cfr -positive plasmids circulating in Escherichia coli of animal origin in Northeast China, Vet Microbiol, 2018, 217:53-57.

15) Xiu-Mei Wang, Zhimin Dong, Stefan Schwarz, Yao Zhu, Xin Hua, Yanhe Zhang, Siguo Liu* and Wanjiang Zhang*. Plasmids of diverse Inc groups mediate the dissemination of the fosfomycin resistance gene fosA3 in Escherichia coli from pigs, chickens and dairy cows in Northeast China. Antimicrob Agents Chemother, 2017, 61(9):e00859.

16) Wanjiang Zhang^#, Xiu-Mei Wang^#, Lei Dai, Xin Hua, Zhimin Dong, Stefan Schwarz, Siguo Liu*. Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the Extended-Spectrum-Lactamase gene bla _CTX-M-14b. Antimicrob Agents Chemother, 2015, 59(2):1337-1340.

17) Hongbin Si^#, Wanjiang Zhang^#, Shengbo Chu, Xiu-Mei Wang, Lei Dai, Xin Hua, Zhimin Dong, Stefan Schwarz, and Siguo Liu*. Novel plasmid-borne multidrug resistance gene cluster including lsa (E) from a linezolid-resistant Enterococcus faecium isolate of swine origin. Antimicrob Agents Chemother, 2015, 59(11):7113-7116.

18) Wanjiang Zhang^#, Xing-Ran Xu^#, Stefan Schwarz, Xiu-Mei Wang, Lei Dai, Hua-Jun Zheng and Siguo Liu*. Characterization of the IncA/C plasmid pSCEC2 from Escherichia coli of swine origin that harbours the multiresistance gene cfr . J Antimicrob Chemother, 2014, 69(2):385-389.

19) Wanjiang Zhang^#, Zong-ji Lu^#, Stefan Schwarz, Rong-Min Zhang, Xiu-Mei Wang, Wei Si, Shen-ye Yu, Li-pingChen and Siguo Liu*. Complete sequence of the bla _NDM-1-carrying plasmid pNDM-AB from Acinetobacter baumannii of food animal origin. J Antimicrob Chemother, 2013, 1681-1682.

20) Xiu-Mei Wang^#, Wanjiang Zhang^#, Stefan Schwarz, Shen-ye Yu, Huifang Liu, Wei Si, Rong-Min Zhang, Siguo Liu. Methicillin-resistant Staphylococcus aureus ST9 from a case of bovine mastitis carries the genes cfr and erm (A) on a small plasmid. J Antimicrob Chemother, 2012, 67:1287-99.

7、专利和标准

1) 刘思国，王秀梅，张万江，李兆利. 一种含有凤尾草和磷霉素的畜禽用复方药物（ZL201410641161）。

2) 华欣，刘思国，张万江. 绵马酚或其衍生物在制备用于预防/或治疗由细菌引起的相关疾病的药物中的用途（ZL201710863942）。

3) 华欣，刘思国，张万江. 新藤黄酸或其衍生物在制备用于预防/或治疗由细菌引起的相关疾病的药物中的用途（ZL201710915184）。

4) 谢芳，刘思国，张万江，张跃灵. 一种广谱抗菌肽及其应用（ZL202010037156）。

8、获得奖励

1) 荣获2014，2016，2018和2019年度所文明职工标兵；

2) 荣获2016-2017年度哈尔滨兽医研究所优秀共产党员；

3) 获建所70周年“青年创新奖”；

4) 鼠疫相关材料获黑龙江省委主要领导批示。